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目的：观察东菱精纯克栓酶（ＤＦ５２１）对裸鼠体内人胃癌及鼻咽癌细胞增殖能力的影响。方法：用免疫组织细胞化学及图像分析定量的方法，研究ＤＦ５２１处理组和对照组之间，裸鼠移植瘤癌细胞ＤＮＡ含量及增殖细胞核抗原（ＰＣＮＡ）表达的差异。结果：胃癌处理组，癌细胞的ＤＮＡ含量及ＰＣＮＡ表达均明显低于对照组（Ｐ＜０．０１）；鼻咽癌处理组，癌细胞ＤＮＡ含量及ＰＣＮＡ表达和对照组之间无明显差异（Ｐ＞０．０５）。结论：ＤＦ５２１对裸鼠体内人胃癌细胞的增殖能力有明显的抑制作用，而对人鼻咽癌细胞的抑制作用不明显
OBJECTIVE: To observe the effect of DF-527 on the proliferation of human gastric cancer and nasopharyngeal carcinoma cells in nude mice. Methods: Immunohistochemistry and image analysis of quantitative methods to study the DF 521 treatment group and the control group, nude mice transplanted tumor DNA content and expression of proliferating cell nuclear antigen (PCNA) differences. Results: The DNA content and the expression of PCNA in cancer cells were significantly lower than those in the control group (P <0.01). There were no significant differences in DNA content and PCNA expression between the NPC and the control groups P> 0.05). CONCLUSION: DF521 can significantly inhibit the proliferation of human gastric cancer cells in nude mice, while it has no obvious inhibitory effect on human nasopharyngeal carcinoma cells