苯磺酸埃曲寇林(Atracurium besylate; ATC)是一种新型竞争性非去极化神经肌肉阻滞药。它没有其它神经肌肉阻滞药的某些主要缺点,例如蓄积作用,也不按常规方式进行代谢,而是在正常体温与生理pH下不依赖酶而降解(即所谓Hofmann消除),小部分则通过酯酶水解。在酸性溶液(pH3.0)中,ATC保持稳定,在冰箱内可保存相当长的时间。低温下行心内直视手术的病人,ATC灭活减慢,复温后分解又加快。血浆假性胆碱酯酶低的病人用ATC后肌松作用不延长。此药起效 Atracurium besylate (benzenesulfonic acid) is a novel competitive non-depolarizing neuromuscular blocker. It has no major drawbacks of other neuromuscular blockers, such as accumulation, nor does it metabolize in the usual way, but rather does not depend on enzymes for degradation at normal body temperature and physiological pH (the so-called Hofmann elimination) Hydrolysis by esterase. In acid solution (pH 3.0), ATC is stable and can be stored in the refrigerator for a considerable amount of time. Patients undergoing open heart surgery under low temperature, ATC inactivation slowed down, after rewarming decomposition and speed up. Plasma pseudo-cholinesterase in patients with low post-ATC muscle relaxant effect is not extended. This medicine works