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目的探讨患者发生药品不良反应(ADR)的特点,加强ADR监测,促进临床合理用药。方法收集惠州市中医医院2014年通过广东省药品不良反应管理平台报告ADR监测网的106例ADR报告,对患者的年龄、性别、给药途径、药物联用情况、ADR累及器官或系统及临床表现等方面进行分类统计和分析。结果 106例ADR报告中,患者年龄最小3岁,最大85岁,其中以大于50岁的患者居多,共57例,占53.7%;发生ADR患者的主要给药途径为静脉滴注;涉及药品共9类,以使用抗感染药品出现ADR最多见,中药制剂次之;两药联用最多见,占51.9%;主要以皮肤及其附件损伤为主,共27例,占25.5%;消化系统、神经系统次之;治疗后56例患者治愈,50例好转。结论由于ADR的发生与多种因素相关,存在一定的不可预见性,因此临床需提高对ADR的重视程度,加强对ADR的监测与报告,减少ADR的发生,保障临床用药安全。
Objective To explore the characteristics of patients with adverse drug reactions (ADR), strengthen the monitoring of ADR and promote clinical rational use of drugs. Methods We collected 106 cases of ADR reported by Huizhou Chinese Medicine Hospital in ADR monitoring network through the ADR management platform in Guangdong Province in 2014 and analyzed the age, gender, route of administration, drug combination, ADR involving organ or system and clinical manifestations And other aspects of classification statistics and analysis. Results In the 106 ADR cases, the youngest patient was 3 years old and the oldest was 85 years old, of which 57 patients (53.7%) were mostly over 50 years of age. The main route of administration for ADR patients was intravenous infusion. 9 categories, the most common use of anti-infective drugs appear ADR, followed by traditional Chinese medicine; the most common two drugs, accounting for 51.9%; mainly the skin and its accessories based injury, a total of 27 cases, accounting for 25.5%; digestive system, Followed by the nervous system; after treatment, 56 patients were cured, 50 patients improved. Conclusion The occurrence of ADR is related to a variety of factors and there is some unpredictability. Therefore, it is necessary to improve the degree of attention paid to ADR clinically, to strengthen the monitoring and reporting of ADR, to reduce the incidence of ADR and to ensure the safety of clinical medication.