论文部分内容阅读
前将真菌引起的甲感染统称为甲真菌病(Onycho—mycosis)。真菌的致病菌谱常随环境因素以及宿主的行为而发生变化,不断产生变迁,出现许多新的致病菌株,给甲真菌病的治疗带来了新问题。由于正常甲板较厚,由致密而坚实的角化上皮所组成,而病甲则更厚,局部用药难以穿透甲板,故甲真菌病在皮肤真菌病中最难治疗。传统的治疗方法是局部外用抗真菌药物,疗效欠佳,且病人不能很好坚持,随着口服抗真菌药物的问世,近年来又合成了几种广谱、高效、安全的口服抗真菌药物,使甲真菌病的治疗取得很大的进展。现综述如下:
A fungal infection caused by the former collectively referred to onychomycosis (Onycho-mycosis). Fungal pathogen spectrum often with environmental factors and the behavior of the host changes, continue to produce changes in the emergence of many new strains of pathogens, the treatment of onychomycosis brought new problems. As the normal deck is thick, composed of dense and solid keratinized epithelium, while the disease is a thicker arm, the topical treatment is difficult to penetrate the deck, so mycosis is the most difficult to treat dermatomycosis. The traditional treatment is topical antifungal drugs, poor efficacy, and the patient can not adhere well, with the advent of oral antifungal agents, in recent years has synthesized several broad-spectrum, efficient and safe oral antifungal agents, Make a great progress in the treatment of onychomycosis. Now summarized as follows: