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目的:观察丹参、心得安对门脉高压大鼠肝纤维化指标及胃肠激素的影响。方法:采用CCL4加酒精饮料制作大鼠门脉高压模型,造模4周后分别给大鼠服用丹参、心得安,造模结束后处死大鼠,颈动脉取血,用放免法检测正常组、模型组、心得安治疗组、丹参治疗组大鼠血浆胃肠激素(胃动素、胃泌素、胰高血糖素)的含量、肝纤维化指标。结果:心得安组CIV、LN、PC与模型组比较无明显差异(P>0.05),HA明显升高(P<0.05)。心得安组胃动素含量与模型组比较无明显改善(P>0.05),胃泌素、胰高血糖素明显下降(P<0.05)。丹参治疗组胃泌素、胃动素、胰高血糖素含量与模型组比较明显下降(P<0.01或P<0.05)),与心得安治疗组比较胃动素、胃泌素、胰高血糖素下降明显(P<0.05)。结论:丹参能有效降低门脉高压大鼠肝纤维化指标,调节胃肠激素,疗效优于心得安治疗组。其作用机理可能与其良好的抗肝纤维化、阻止肝硬化形成、调节胃肠激素水平、改善肝功能等作用有关。
Objective: To observe the effects of Salvia miltiorrhiza and propranolol on hepatic fibrosis and gastrointestinal hormones in rats with portal hypertension. Methods: CCL4 and alcoholic beverages were used to make rat portal hypertension model. Rats were given Salvia miltiorrhiza for 4 weeks after modeling. Rats were sacrificed at the end of the model establishment and carotid arteries were taken. The normal group was detected by radioimmunoassay. The content of plasma gastrointestinal hormones (motilin, gastrin, glucagon) and the indexes of liver fibrosis in model group, propranolol treatment group and Salvia miltiorrhiza treatment group. Results: There was no significant difference (P> 0.05) between CTP, LN and PC in model group and HA group (P <0.05). There was no significant improvement in motilin group compared with model group (P> 0.05), and gastrin and glucagon decreased significantly (P <0.05). Compared with the model group, the contents of gastrin, motilin and glucagon in the Salvia miltiorrhiza group were significantly decreased (P <0.01 or P <0.05), and the levels of motilin, gastrin, pancreatic hyperglycemia Supression decreased significantly (P <0.05). Conclusion: Radix Salviae Miltiorrhizae can effectively reduce the indexes of liver fibrosis in rats with portal hypertension and regulate gastrointestinal hormones. Its mechanism of action may be related to its good anti-fibrosis, prevent the formation of cirrhosis, regulate gastrointestinal hormone levels, improve liver function.