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用免疫组化ＡＢＣ法对９２例胃癌的石蜡包埋标本进行了ｐ５３和ｃ－ｅｒｂＢ－２基因蛋白表达的研究。结果显示：９２例胃癌ｐ５３、ｃ－ｅｒｂＢ－２蛋白表达的阳性率分别为３８．０％和１４．１％；ｐ５３表达主要位于细胞核内，而ｃ－ｅｒｂＢ－２表达主要位于细胞膜，ｐ５３及ｃ－ｅｒｂＢ－２表达与胃癌患者的性别、年龄、原发灶部位、淋巴结及远处转移、肿瘤分期以及病理类型、分级均无明显关系。ｐ５３阳性表达的胃癌患者生存期明显低于ｐ５３阴性者，而ｃ－ｅｒｂＢ－２表达与胃癌患者的生存期无关；ｐ５３与ｃ－ｅｒｂＢ－２二者阳性表达之间亦无关。５例ｐ５３及ｃ－ｅｒｂＢ－２表达的阳性者预后极差，提示，癌基因的异常表达对预后的估计具有辅助意义。
The expression of p53 and c-erbB-2 gene proteins in 92 paraffin-embedded specimens of gastric cancer was studied by immunohistochemical ABC method. The results showed that the positive rates of p53 and c-erbB-2 protein expression in gastric cancer were 38.0% and 14.1%, respectively; the expression of p53 was mainly located in the nucleus, while the expression of c-erbB-2 was mainly located in the cell membrane, p53 and There was no significant relationship between the expression of c-erbB-2 and the gender, age, primary tumor site, lymph node and distant metastasis, tumor stage, pathological type, and grade of gastric cancer. The survival time of patients with p53-positive gastric cancer was significantly lower than that of p53-negative patients. The expression of c-erbB-2 was not associated with the survival of gastric cancer patients. There was no correlation between the positive expression of p53 and c-erbB-2. The positive results of 5 cases of p53 and c-erbB-2 expression were very poor, suggesting that the abnormal expression of oncogenes has an auxiliary significance for the estimation of prognosis.