近年来有关一氧化氮(NO)在内耳方面的研究已经取得了突飞猛进的进展。一氧化氮合酶(NOS)在内耳的分布及一氧化氮在内耳的产生部位均已被确定。一氧化氮对维持内耳功能的重要性,尤其是其作为神经递质所发挥的生理功能,已趋于明朗。越来越多的研究表明,过量的一氧化氮在内耳疾病的产生过程中起着重要的作用。基于内耳疾病产生的机理,已研究出许多有效,针对性强的预防和治疗手段。本文对一氧化氮在内耳的研究作一综述。 In recent years, research on nitric oxide (NO) in the inner ear has made rapid progress. Nitric oxide synthase (NOS) distribution in the inner ear and nitric oxide in the inner ear have been identified. The importance of nitric oxide to maintain the inner ear function, especially its physiological function as a neurotransmitter, has tended to be clear. More and more studies have shown that excess nitric oxide plays an important role in the pathogenesis of inner ear diseases. Based on the mechanism of inner ear disease, many effective and targeted preventive and therapeutic tools have been developed. This article reviews the research on nitric oxide in the inner ear.