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目的 探讨脑脊液中不同蛋白质成分对中枢神经系统感染患儿的临床价值。方法 应用免疫透射比浊法 ,速率散射比浊法等测定 4 7例中枢神经系统感染患儿脑脊液微量总蛋白 (m TP) ,微量白蛋白 (m ALB) ,免疫球蛋白 (Ig)和补体C3 、C4一系列蛋白质指标 ,并与非感染组对照。结果 非感染组各项指标均在正常范围 ,各组脑膜炎m TP、m ALB、Ig均有不同程度的升高 ,且化脓性脑膜炎与结核性脑膜炎组增加更明显。其中化脓性脑膜炎组以IgM升高更明显 ,结核性脑膜炎组以IgG升高最明显。化脓性脑膜炎与结核性脑膜炎组补体C3 、C4阳性率显著高于对照组和病毒性脑膜炎组。结论 中枢神经系统感染患儿血脑屏障受到不同程度损害 ,各种蛋白成分的检测对三种脑膜炎的诊断和鉴别诊断有重要临床意义
Objective To investigate the clinical value of different protein components in cerebrospinal fluid (CSF) in children with central nervous system infection. Methods Immunomagnetic turbidimetry and rate nephelometry were used to determine the levels of mTP, m ALB, Ig and C3 in 47 children with CNS infection. , C4 a series of protein indicators, and non-infected group control. Results The indexes of non-infected group were in the normal range, and the levels of m TP, m ALB and Ig in each group were increased to some extent, and the increase of purulent meningitis and tuberculous meningitis was more obvious. Which purulent meningitis group increased more significantly IgM, tuberculous meningitis group with IgG was the most obvious. Purulent meningitis and tuberculous meningitis complement C3, C4 positive rate was significantly higher than the control group and viral meningitis group. Conclusion The blood-brain barrier in children with central nervous system infection is damaged to varying degrees. The detection of various protein components has important clinical significance in the diagnosis and differential diagnosis of three kinds of meningitis