论文部分内容阅读
本文观察了灯盏花浸膏对小鼠常压耐缺氧、离体豚鼠心脏灌流、体外家兔血小板聚集及家兔脑血流等的影响。发现口服灯盏花毒性较小,一次口服相当于生药80g/kg时,三天内未见小鼠死亡。口服灯盏花60g/kg1～2hr内,具有保版小鼠常压耐缺氧作用。在家兔耳静脉注射1g/kg时,具有增加家兔脑血流量及外周血流量的作用,持续时间为17min。在家兔体外血浆药物浓度为23mg/ml时,该药能抑制家兔血小板聚集。当5%灯盏花提取液进行豚鼠离体心脏灌流时浓度为0.25mg/ml和0.5mg/ml,均能增加冠脉流量。
This article observed the effects of Erigeron breviscapus extract on hypoxia-resistance, isolated cardiac guinea pig perfusion, rabbit platelet aggregation in vitro and cerebral blood flow in rabbits. It was found that oral breviscapitis was less toxic, and once orally equivalent to crude drug 80g/kg, no mice died within three days. Oral breviscapus 60g/kg 1 ~ 2hr, with plateau mice normal pressure hypoxia. When rabbit ear vein was injected with 1g/kg, it had the effect of increasing cerebral blood flow and peripheral blood flow in rabbits for a duration of 17 minutes. When the plasma concentration of rabbit plasma was 23 mg/ml in vitro, the drug could inhibit platelet aggregation in rabbits. When 5% Erigeron breviscapus extract was used for guinea pig heart perfusion, the concentrations of 0.25 mg/ml and 0.5 mg/ml could increase coronary flow.