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目的 研究急性脑梗塞患者血清白细胞介素６（ＩＬ－６） 的变化，进而探讨其临床意义。方法 采用放免法检测４０ 例急性脑梗塞患者血清ＩＬ－６ 水平，并与２０ 例健康人作对照。结果 脑梗塞患者急性期血清ＩＬ－ ６ 水平明显高于恢复期（Ｐ＜０－０１） 。恢复期血清ＩＬ－６ 稍高于正常水平，与正常对照组比较无显著性差异（ Ｐ＞０－０５） 。急性期血清ＩＬ－ ６ 升高的程度与梗塞灶大小密切相关。结论 脑梗塞急性期血清ＩＬ－６ 升高，恢复期已降至基本正常。脑缺血、缺氧及脑组织损伤引起的急性应激反应可能是脑梗塞急性期血清ＩＬ－６ 升高的重要机制。ＩＬ－６ 升高对缺血神经元可能具有保护作用。
Objective To study the changes of serum interleukin-6 (IL-6) in patients with acute cerebral infarction and to explore its clinical significance. Methods Serum levels of IL-6 in 40 patients with acute cerebral infarction were measured by radioimmunoassay and compared with 20 healthy controls. Results Serum levels of IL-6 in patients with acute cerebral infarction were significantly higher than those in patients with recovery (P <0-01). Convalescent serum IL-6 slightly higher than the normal level, compared with the normal control group no significant difference (P> 0-05). The level of serum IL-6 in acute stage is closely related to the size of infarction. Conclusions The level of IL-6 in the acute stage of cerebral infarction is elevated, and the recovery period has been reduced to normal. Acute stress response induced by cerebral ischemia, hypoxia and brain injury may be an important mechanism of elevated serum IL-6 in acute cerebral infarction. Elevated IL-6 may have protective effects on ischemic neurons.