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随着抗痨药物的广泛应用.该类药物引起的副反应也必须引起重视。尤其是血液学异常,一旦发生处理困难,如不及时停药后果严重。甚至导致死亡。我科近两年来发现三例因抗痨药物引起的血液学异常,复习国内外有关文献31篇有52例血液学异常,加上我科三例,共计55例。现整理报告如下: 国内有关抗痨药物副反应文献13篇,报告血液学异常22例。其中粒细胞缺乏居首位,共16例占73％,因氨硫脲或含氨硫脲组药物引起较多,见表1
With the widespread use of anti-tuberculosis drugs, side effects caused by these drugs must also be taken seriously. In particular, hematological abnormalities, once the treatment is difficult, if not promptly discontinued serious consequences. Even lead to death. Three cases of hematological abnormalities caused by anti-tuberculosis drugs were found in our hospital in the past two years. There were 52 hematological abnormalities in 31 articles reviewed at home and abroad, and 55 cases in our department. Are collated as follows: Domestic anti-tuberculosis drug side effects literature 13 articles, 22 cases of hematological abnormalities reported. Among them, neutropenia ranks first, a total of 16 cases accounted for 73%, due to thiazolidinyl or thiourea group caused more drugs, see Table 1