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本文评述神经垂体激素对睾丸机能的调节。根据离体条件下对睾丸雄激素生物合成的影响,在大鼠睾丸中存在精氨酸加压素(AVP)样物质以及AVP降解酶等发现,提示AVP可能作为一种性腺内的肽起到在局部调制雄激素生物合成的作用。AVP在调制睾丸Leydig细胞甾体生物合成方面的自身分泌(autocrine)或旁分泌(paracrine)作用可以作为一个范例,用于理解性腺内的局部激素调节机制。神经垂体激素抑制睾丸雄激素合成:Leydig细胞是睾丸内的主要雄激素产生细胞,其甾体生成机能主要受垂体LH的调节。此外,许多别的因素也必定调节着Leydig细胞对LH的反应性。除
This article reviews the regulation of neurohum pituitary hormones on testicular function. According to the effect of exogenous conditions on testicular androgen biosynthesis, the presence of arginine vasopressin (AVP) -like substances and AVP-degrading enzymes in the testis of rats suggests that AVP may act as a peptide of the gonadal The role of androgen in the local modulation of biosynthesis. The autocrine or paracrine effects of AVP in modulating testicular Leydig cell steroid biosynthesis can be used as an example to understand the local hormonal regulatory mechanism within the gonads. Nerve pituitary hormone inhibits testosterone synthesis: Leydig cells are the major androgen-producing cells in the testes whose steroidogenic function is predominantly regulated by pituitary LH. In addition, many other factors must also regulate the reactivity of Leydig cells to LH. except