基质金属蛋白酶组织抑制剂(tissue inhibitor of metalloproteinases,TIMPs)是近年来发现的有抑制胶原酶即基质金属蛋白酶(matrix metalloproteinases,MMPs)活性的一组多功能因子家族,它通过对MMPs的抑制,在正常细胞外基质(extracellular matrix,ECM)改建和各种病理过程中发挥重要作用。研究表明动脉损伤术后血浆中MMPs的含量增加,提示MMPs的表达与血管损伤术后再狭窄的形成有关。MMPs活性能被TIMPs抑制,进而降低MMPs的表达。现已成为防治血管成形术后再狭窄的主要目标。 Tissue inhibitor of metalloproteinases (TIMPs) are a family of multifunctional factors found in recent years that inhibit the activity of collagenases, namely, matrix metalloproteinases (MMPs). By inhibiting MMPs, Normal extracellular matrix (ECM) remodeling and a variety of pathological processes play an important role. Studies have shown that plasma levels of MMPs increased after arterial injury, suggesting that the expression of MMPs is associated with the formation of restenosis after vascular injury. The activity of MMPs can be inhibited by TIMPs, and then reduce the expression of MMPs. Has now become the main goal of prevention and treatment of restenosis after angioplasty.