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应用含有高效价空肠弯曲菌抗体的急性运动性轴索型格林-巴利综合征病人的血清浸泡8只在体新西兰兔坐骨神经。14天后病理检查显示4只兔的坐骨神经均有20%～30%的纤维发生轴索变性,而髓鞘相对正常。而其他神经疾病组血清、健康成人组血清做同样实验获阴性病理结果。本实验表明:AMAN 患者血清中含有致病因子,此致病因子可能是抗空肠弯曲菌抗体并介导了神经轴索的损害。
Serum from patients with acute motor axonal Guillain-Barre syndrome containing high titer anti-Campylobacter jejuni antibodies were used to soak 8 sciatic nerves in vivo in New Zealand rabbits. Pathological examination 14 days later revealed that 20% to 30% of axons degenerated in the sciatic nerve of 4 rabbits, while myelin sheath was relatively normal. The other neurological disease serum, healthy adults do the same experiment serum negative pathology results. This experiment shows that: AMAN patients serum containing virulence factors, the causative agent may be antibodies against Campylobacter jejuni and mediate axonal damage.