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目的探讨肝VX2瘤模型MR扩散成像特征。方法新西兰大白兔35只,采用块种植的方法,一期预实验:皮下种植14只,肝内种植6只;二期肝内种植12只,另3只做正常对照。对包括二期肝内种植在内的15个肿瘤于种植前后行定期扩散加权成像(DWI)与MR检查。以表观扩散系数(ADC)值等为指标进行统计分析。结果(1)一期预实验,皮下种植成功率29%(4/14),肝内种植成功率33%(2/6);二期肝内种植成功率83%(10/12)。(2)VX2瘤在DWI上呈高信号,边缘清楚。正常组与VX2瘤实验组b值为100和300s/mm2时ADC值分别为(2.57±0.26)mm2/s、(1.73±0.31)mm2/s、(1.87±0.25)mm2/s与(1.57±0.23)mm2/s(F=43.26,P<0.001)。随b值增大,病灶信号降低;ADC图上病灶呈低信号;不同b值之间病灶ADC值差异有统计学意义(P<0.05);b=100s/mm2病灶与正常肝脏之间ADC值差异有统计学意义(P<0.01)。(3)VX2瘤发展迅速,易发生肺、肝、纵隔等处转移。结论DWI在反映肝VX2瘤内部水分子运动、发现与追踪病灶进展等方面有重要价值。
Objective To investigate the characteristics of MR diffusion imaging in hepatic VX2 tumor model. Methods New Zealand white rabbits 35, using block planting method, a pre-experiment: subcutaneous implantation of 14, 6 intrahepatic planting; two intrahepatic 12, the other three as a normal control. Periodic diffusion-weighted imaging (DWI) and MR imaging were performed before and after implantation in 15 tumors including second-stage intrahepatic implants. Apparent diffusion coefficient (ADC) value as an indicator for statistical analysis. Results (1) A preliminary experiment showed that the success rate of subcutaneous implantation was 29% (4/14) and the success rate of intrahepatic implantation was 33% (2/6). The success rate of second intrahepatic implantation was 83% (10/12). (2) VX2 tumor showed a high signal on DWI with clear edge. The ADC values were (2.57 ± 0.26) mm2 / s, (1.73 ± 0.31) mm2 / s, (1.87 ± 0.25) mm2 / s and (1.57 ± 0.23) mm2 / s (F = 43.26, P <0.001). With the b value increased, lesion signal decreased; ADC lesion showed a low signal; different b value between the lesion ADC value was statistically significant (P <0.05); b = 100s / mm2 lesion and normal liver ADC value The difference was statistically significant (P <0.01). (3) VX2 tumors develop rapidly, prone to lung, liver, mediastinal metastasis. Conclusion DWI is of great value in reflecting the water molecule movement in liver VX2 tumor and finding and tracking the progress of the lesion.