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目的探讨葡萄糖酸钙、缩宫素、米索前列醇联合应用预防剖宫产产后出血的效果。方法选385例剖宫产者随机分三组：单药组120例(缩宫素组)；两联药组(缩宫素加米索前列醇组)130例；三联药组(葡萄糖酸钙加缩宫素加米索前列醇组)135例。结果测得术中出血及术毕阴道积血量：单药组(300±50．24)ml,两联药组(220±30．83)ml,三联药组(150±45．52)ml,各组出血量比较差异有统计学意义(P＜0．05)；术后2h累计出血：单药组(400±45．53)ml,两联药组(260±60．43)ml,三联药组(210±50．54)ml,各组出血量比较差异有统计学意义(P＜0．05)。结论三药联合应用能更好地预防剖宫产术中及术后出血,且用药方便、安全、经济。
Objective To investigate the effect of combined application of calcium gluconate, oxytocin and misoprostol in preventing bleeding after cesarean section. Methods 385 cases of cesarean section were randomly divided into three groups: single drug group of 120 cases (oxytocin group); two combined drug group (oxytocin plus misoprostol group) 130 cases; triple drug group (calcium gluconate Plus oxytocin plus misoprostol group) 135 cases. Results The intraoperative blood loss and postoperative vaginal hemorrhage volume were measured in single drug group (300 ± 50.24) ml, two-drug group (220 ± 30.83) ml, triple drug group (150 ± 45.52) ml , Bleeding in each group was significantly different (P <0.05); 2h postoperative cumulative hemorrhage: single drug group (400 ± 45.53) ml, two combined drug group (260 ± 60.43) ml, The triple drug group (210 ± 50.54) ml, bleeding in each group was significantly different (P <0.05). Conclusion The combination of the three drugs can better prevent bleeding during and after cesarean section, and is convenient, safe and economical.