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目的探讨鼠神经生长因子联合单唾液酸神经节苷酯治疗周围神经损伤的疗效。方法 60例桡神经损伤患者,随机分为鼠神经生长因子联合单唾液酸神经节苷酯组f联合组)和鼠神经生长因子组(单用组),每组均为30例。联合组应用鼠神经生长因子20ug+0.9%氯化钠2ml溶解,肌注,1次/d和5%葡萄糖250m1+单唾液酸神经节苷酯40mg,静滴,1次,d联合治疗共1个疗程(308),鼠神经生长因子组单纯应用鼠神经生长因子20ug+0.9%氯化钠2ml溶解,肌注,1次,d共治疗1个疗程(3od);30d后,通过临床表现和肌电图检查结果,分析疗效。结果联合组疗效明显优于单用组,差异有统计学意义(p<0.05)。结论鼠神经生长因子与单唾液酸神经节苷酯治疗周围神经损伤中具有协同作用.值得临床推广。
Objective To investigate the therapeutic effect of nerve growth factor combined with monosialoganglioside on peripheral nerve injury. Methods Sixty patients with radial nerve injury were randomly divided into three groups: the combination group of NGF and monosialoganglioside group (f group) and the group of rat nerve growth factor (single group), 30 in each group. The combination group was treated with 20ug of mouse nerve growth factor and 2ml of 0.9% sodium chloride dissolved, intramuscular injection, 1 / d and 5% glucose 250m1 + monosialoganglioside 40mg, intravenous infusion, 1 time, d combined treatment a total of 1 Treatment (308), the rat NGF group was treated with 20ug of 0.9% sodium chloride and 2ml of mouse nerve growth factor alone, intramuscularly, once and d for 1 course of treatment (3od). After 30 days, ECG test results, analysis of efficacy. Results The combined group was significantly better than the single group, the difference was statistically significant (p <0.05). Conclusion NGF and monosialoganglioside have a synergistic effect in the treatment of peripheral nerve injury, which is worthy of clinical application.