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理想的肿瘤标志物灵敏度高、特异度好、操作方便,对早期发现、诊断肿瘤以及判断预后具有重要意义。作为一种新型的肿瘤标志物,人附睾分泌蛋白(HE4)在卵巢癌组织中高表达,癌旁组织、正常组织及良性肿瘤中不同程度低水平表达,正常卵巢组织上皮不表达,是卵巢恶性肿瘤诊断及鉴别诊断的重要指标。本文将就HE4的生物学特性及临床应用情况予以综述。1HE4的生物学特性1.1HE4的分子生物学特点HE4又称核心表位蛋白
The ideal tumor markers high sensitivity, specificity, easy to operate, early detection, diagnosis of cancer and prognosis of great significance. As a new tumor marker, human epididymal secreted protein (HE4) is overexpressed in ovarian cancer tissues, with low-level expression in adjacent tissues, normal tissues and benign tumors, but not in ovarian epithelial tissues Diagnosis and differential diagnosis of important indicators. This article will review the biological characteristics and clinical application of HE4. 1HE4 biological characteristics 1.1HE4 molecular biology HE4, also known as the core epitope protein