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肝外胆管腺瘤是否可演变为恶性肿瘤,在文献中报道很少。作者等对43例经手术及病理证实的肝外胆管癌患者(年龄为30～80岁,平均男性64.8±9.1岁,女性62.3±16.2岁,男女之比为1.9:1)的切除标本。分别作2～30次HE染色的组织切片及组织病理学检查,试图了解肝外胆管中演变为癌的情况。肝外胆管癌的大体标本,可分为乳头状或息肉样癌、结节状癌、及扁平型或溃疡型癌三种类型。所有乳头状或息肉样癌,在组织学上均为乳头状腺癌,而多数扁平型或溃疡型肿瘤以管状腺癌或未分化癌为主。约半数的结节状癌为乳头状腺癌,余为管状腺癌或未分化癌。本组4例无浸润的早期肝外胆管癌肉眼
Whether extrahepatic bile duct adenomas can evolve into malignant tumors is rarely reported in the literature. The author et al. performed a resection specimen of 43 cases of extrahepatic cholangiocarcinoma confirmed by surgery and pathology (age 30-80 years, mean male 64.8±9.1 years, female 62.3±16.2 years, male to female ratio 1.9:1). Histopathological examinations were performed with HE staining for 2 to 30 times respectively to try to understand the evolution of cancer into the extrahepatic bile ducts. The gross specimens of extrahepatic cholangiocarcinoma can be divided into three types: papillary or polypoid carcinoma, nodular carcinoma, and flat or ulcerated carcinoma. All papillary or polypoid carcinomas are histologically papillary adenocarcinomas, whereas most flat or ulcerous tumors are tubular adenocarcinoma or undifferentiated carcinoma. About half of the nodular carcinomas are papillary adenocarcinomas and the rest are tubular adenocarcinomas or undifferentiated carcinomas. 4 cases of non-invasive early extrahepatic bile duct cancer in the group