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目的：探讨梗阻性黄疸状态下机体发生脓毒血的机制。方法：SD大鼠分为两组，假手术组(sham operation，SH组)，梗阻性黄疸组(obstruction jaundice,OJ组)。通过建立梗阻性黄疸的动物模型，观察梗阻性黄疸大鼠肠道细菌易位的情况。结果：OJ组大鼠厌氧菌培养的阳性率明显高于SH组。结论：梗阻性黄疸时肠道内微生态平衡紊乱，肠道细菌发生易位，这可能成为梗阻性黄疸患者易感性增高的原因之一。“,”Objective: To probe the machanism of susceptibility of the patients with obstructive jaundice. Methods: Rats weredivided into 2 groups. SH group and OJ group. The bacterial transloeation in intestinal tracts in rats were studied by using themodel of obstructive jaundice. Results: It is showed that the positive rate of the anaerobic becteriunm culture in the group ofOJ group was 43.75% .But negative in the group of shan operation. Conclusion: The bacterial traslocation may be one of thereasons to increase of infection rate in the patients with obstructive jaundice.