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目的:筛选防治去卵巢大鼠骨质疏松的有效补肾中药。方法: 3月龄雌性 Wistar大鼠 54只,体重(200 ± 30)g,分成对照组 30只和成模后中药治疗组 24只。对照组分为 3个亚组,每组 10只;中药治疗分为 4个亚组, 每组6只。用切除大鼠双侧卵巢的方法建立骨质疏松模型,以单味补肾中药为实验药物,用骨计量学的方法研究 它们对去卵巢大鼠骨质疏松的防治作用。结果:回味中药均可抑制去卵巢大鼠骨转换,减少骨吸收,杜仲的作用最 明显。结论:回味中药对去卵巢大鼠骨丢失均有不同程度的抑制作用。
Objective: To screen and effectively prevent and treat osteoporosis in ovariectomized rats. METHODS: A total of 54 3-month-old female Wistar rats were weighed (200 ± 30) g and divided into 30 control groups and 24 Chinese medicine treatment groups. The control components were 3 subgroups, 10 in each group; Chinese medicine treatment was divided into 4 subgroups, 6 in each group. The model of osteoporosis was established by removing the bilateral ovaries of rats. The mono-tonic kidney-invigorating herbs were used as experimental drugs, and their osteoporosis prevention effects in ovariectomized rats were studied by bone quantification. RESULTS: Aftertaste can inhibit the bone turnover in ovariectomized rats and reduce bone resorption. The effect of Eucommia is most obvious. Conclusion: Aftertaste herbs have different degrees of inhibition on bone loss in ovariectomized rats.