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目的：探讨人工合成生长抑素施他宁治疗食管胃底静脉曲张破裂出血的疗效。方法：施他宁治疗组６５例，０．２５ｍｇ静注后，将３ｍｇ加入５％葡萄糖５００ｍｌ中连续静滴，１２ｈ１次；神经垂体素治疗组１００例，２０Ｕ静滴，８～１２ｈ１次；两组均连续用药７２ｈ。对两组患者止血率、再出血率、急诊手术率和死亡率进行比较。结果：施他宁治疗组２４ｈ和７２ｈ内止血率分别为７３．９％和８３．１％，神经垂体素组分别为４３．０％和５２．０％（Ｐ＜０．０１），两组再出血发生率分别为１２．３％和３７．０％（Ｐ＜０．０１），急诊手术率分别为１３．９％和１８．０％，死亡率分别为６．２％和１８．０％（Ｐ＜０．０５），副作用发生率分别为４．６％和４３．０％（Ｐ＜０．０１）。结论：施他宁是治疗食管胃底静脉曲张破裂出血的有效药物。
Objective: To investigate the effect of synthetic somatostatin in the treatment of esophageal variceal bleeding. Methods: Sitatin treatment group 65 cases, 0.25mg intravenous injection, 3mg 5% glucose 500ml continuous intravenous infusion, 12h1 times; neurophysin pituitary hormone treatment group 100 cases, 20U intravenous infusion, 8 ~ 12h1 times; two Group were continuous medication 72h. Hemostatic rate, rebleeding rate, emergency operation rate and mortality of two groups were compared. Results: The rates of hemostasis were 73.9% and 83.1% in the group of statin and 43.0% and 52.0% of the group in the neuropituptone group (P <0.01) The rates of rebleeding were 12.3% and 37.0%, respectively (P <0.01). The rates of emergency surgery were 13.9% and 18.0% respectively, and the mortality rates were 6.2% and 18.0% % (P <0.05). The incidence of side effects were 4.6% and 43.0% respectively (P <0.01). Conclusion: Sitaton is an effective drug for the treatment of esophageal and gastric variceal bleeding.