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[目的]检测凋亡抑制因子Livin在胃癌组织中的表达情况,探讨其与胃癌的关系及作用机制。[方法]采用免疫组化SP法检测Livin在247例胃癌及30例癌旁组织中的表达,并分析Livin表达与胃癌临床病理因素之间的关系。[结果]Livin在胃癌组织的阳性表达率显著高于癌旁组织(57.9%vs6.67%,P<0.01)。Livin蛋白表达与胃癌的浆膜反应类型、Borra-mann分型、浸润深度、淋巴结转移分站、TNM分期显著性相关(P<0.05)。[结论]Livin作为一个新的凋亡抑制基因,它的激活与胃癌发生、发展相关,可能是胃癌诊断和治疗的潜在靶点。
[Objective] To detect the expression of Livin, an inhibitor of apoptosis, in gastric cancer tissues, and to explore its relationship with gastric cancer and its mechanism of action. [Methods] Immunohistochemical SP method was used to detect the expression of Livin in 247 cases of gastric cancer and 30 cases of adjacent tissues. The relationship between Livin expression and clinicopathological factors of gastric cancer was analyzed. [Results] The positive expression rate of Livin in gastric cancer tissues was significantly higher than that in adjacent tissues (57.9% vs 6.67%, P<0.01). Livin protein expression was significantly correlated with serosal response type, Borra-mann type, infiltration depth, lymph node metastasis, and TNM staging of gastric cancer (P<0.05). [Conclusion] Livin is a new apoptosis-suppressor gene. Its activation is related to the occurrence and development of gastric cancer. It may be a potential target for the diagnosis and treatment of gastric cancer.