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目的:探讨手术后早期腹腔内化疗对进展期胃癌的治疗效果。方法:手术治疗进展期胃癌患者286例随机分为观察组146例,对照组140例,分别给予腹腔内化疗和静脉化疗,比较2组术后水电解质平衡、出血、伤口愈合情况,吻合口瘘、十二指肠残端瘘、术后粘连性或炎性肠梗阻等并发症发生率,化疗药物不良反应及生存情况。结果:2组术后水电解质平衡、出血、伤口愈合情况,吻合口漏、十二指肠残端瘘、术后炎性或粘连性肠梗阻,恶心呕吐等不良反应发生率比较差异无统计学意义(P>0.05);观察组术后同期腹腔积液发生率、腹腔转移率低于对照组(P<0.05),且同期生存率高于对照组(P<0.05)。结论:术后早期腹腔内化疗能有效改善进展期胃癌患者的预后。
Objective: To investigate the effect of early postoperative intraperitoneal chemotherapy on advanced gastric cancer. Methods: A total of 286 patients with advanced gastric cancer undergoing surgery were randomly divided into observation group (146 cases) and control group (140 cases). Intraperitoneal chemotherapy and intravenous chemotherapy were given respectively. Electrolyte balance, bleeding, wound healing, anastomotic fistula , Duodenal stump fistula, postoperative adhesions or inflammatory bowel obstruction and other complications, chemotherapy adverse drug reactions and survival. Results: There was no significant difference in the incidence of postoperative water and electrolyte balance, hemorrhage, wound healing, anastomotic leak, duodenal stump fistula, postoperative inflammatory or adhesive intestinal obstruction, nausea and vomiting and other adverse reactions (P> 0.05). The incidence of peritoneal effusion and peritoneal metastasis in the observation group was lower than that in the control group (P <0.05), and the survival rate at the same period was higher than that of the control group (P <0.05). Conclusion: Early postoperative intraperitoneal chemotherapy can effectively improve the prognosis of patients with advanced gastric cancer.