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目的:研究血清血管内皮生长因子(VEGF)水平在冠心病(CHD)诊断和冠状动脉介入治疗(PCI)中的临床意义。方法:将CHD组62例和非CHD组(对照组)20例,患者行冠状动脉造影(CAG)。CHD组中,按照美国心脏病学会和美国心脏协会(ACC/AHA)2000年解剖风险分组法分为低危(A亚组,23例),中危(B亚组,21例),高危(C亚组,18例)3组,组中部分患者行即刻PCI。使用酶联免疫吸附测定法(ELISA)检测所有患者CAG前和术后(包括CAG或PCI)0.5h血清VEGF浓度。结果:在CHD组中血清VEGF水平明显高于对照组(P<0.01),A亚组与对照组差异无统计学意义(P>0.05),但明显低于B组(P<0.05)和C组(P<0.01)。B组,C组均明显高于对照组(P<0.01),C亚组明显高于B组(P<0.01)。单纯行CAG未作PCI者(60例,包括对照组)前后VEGF血清浓度差异无统计学意义(P>0.05),CAG后即行PCI组(22例)术后明显低于术前(P<0.01),且术后VEGF水平与对照组差异无统计学意义(P>0.05)。结论:CHD患者血清VEGF浓度明显高于非CHD患者,血清VEGF浓度与CHD患者冠状动脉病变的危险分层有密切关系且PCI后明显降低。
Objective: To investigate the clinical significance of serum vascular endothelial growth factor (VEGF) in the diagnosis of coronary heart disease (CHD) and coronary intervention (PCI). Methods: Sixty-two CHD patients and 20 non-CHD patients (control group) underwent coronary angiography (CAG). According to the American College of Cardiology and the American Heart Association (ACC / AHA) 2000 Anatomy Risk Grouping Method, the patients were divided into low risk group (A group, 23 cases), middle risk group (B group, 21 cases), high risk C subgroup, 18 cases) 3 groups, part of the group of patients with immediate PCI. Serum VEGF concentrations were measured at 0.5 h before and after CAG (including CAG or PCI) using enzyme-linked immunosorbent assay (ELISA). Results: The level of serum VEGF in CHD group was significantly higher than that in control group (P <0.01). There was no significant difference between group A and control (P> 0.05), but significantly lower than that in group B (P <0.05) Group (P <0.01). B and C groups were significantly higher than the control group (P <0.01), C subgroup was significantly higher than the B group (P <0.01). There was no significant difference in the serum VEGF levels before and after simple CAG without PCI (60 cases, including the control group) (P> 0.05), but after CAG, the PCI group (22 cases) ), And there was no significant difference in VEGF level between the two groups (P> 0.05). Conclusions: Serum VEGF concentration in patients with CHD is significantly higher than that in non-CHD patients. Serum VEGF concentration is closely related to the risk stratification of coronary artery disease in patients with CHD and is significantly lower after PCI.