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病理生理一氧化碳自呼吸道吸入后,在肺泡内与血液中的血红蛋白结合,形成碳氧血红蛋白。由于碳氧血红蛋白不能携带氧气,致使血液携氧能力降低,引起组织缺氧。血红蛋白能与氧、一氧化碳等多种气体结合,这种结合是可逆性的。一氧化碳进入人体后,即与氧相竞争,由于一氧化碳与血红蛋白的亲和力比氧大210倍以上,故吸入的一氧化碳含量为吸入空气中氧含量的1/210时,即具有与氧相等的竞争能力。通常肺泡空气含氧量为15容量%,因此只要吸入空气中含15/210即0.07%低浓度一氧化碳一定时间后,血液中就有一半量的血红蛋白与一氧化
Pathophysiology Carbon monoxide inhalation from the respiratory tract, the alveolar and hemoglobin in the blood to form carboxyhemoglobin. Because carboxyhemoglobin can not carry oxygen, resulting in lower blood oxygen carrying capacity, causing tissue hypoxia. Hemoglobin and oxygen, carbon monoxide and other gases combined, this combination is reversible. Carbon monoxide into the human body, that is, competition with oxygen, since the affinity of carbon monoxide and hemoglobin more than 210 times larger than oxygen, so inhaled carbon monoxide content of inhaled air oxygen content of 1/210, that is, with oxygen equal competitive ability. Usually alveolar air oxygen content of 15% by volume, so long as the inhalation of air containing 15/210 or 0.07% of low carbon monoxide for a certain period of time, there is half of the blood hemoglobin and monoxide