核因子-κB(NF-κB)是一组分布和作用均十分广泛的转录因子,在机体免疫应答、炎症反应等多种生理、病理过程中发挥重要作用。研究发现,幽门螺杆菌(Hp)感染与许多疾病有关,如慢性胃炎、胃溃疡、胃癌等。Hp感染后能激活NF-κB,而NF-κB激活可以导致其炎症相关因子,如IL-8、IL-1、 Nuclear factor-κB (NF-κB) is a group of transcription factors that are widely distributed and have a role in the body’s immune response, inflammation and other physiological and pathological processes play an important role. The study found that Helicobacter pylori (Hp) infection and many diseases, such as chronic gastritis, gastric ulcer, stomach cancer. Hp infection can activate NF-κB, and NF-κB activation can lead to inflammation-related factors such as IL-8, IL-1,