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采用碘化油与大剂量阿霉素、丝裂霉素、顺氯铵铂等化学栓塞剂,经导管对癌灶及肿瘤血管进行充分栓塞,并用较大剂量白细胞介素-2、α-干扰素经肝动脉灌注行过继免疫,治疗124例次中晚期原发性肝癌(包括2例肝癌破裂出血)。其中单纯型Ⅱ期35例次,Ⅲ期2例次;硬化型Ⅱ期82例次,Ⅲ期3例次;炎症型Ⅱ期2例次。经治疗总有效率达93.5%,其中瘤体缩小50%以上者达32.3%。到目前为止,全组治疗后平均生存期达7.6个月。但重复栓塞治疗4次以上的6例中,4例产生侧枝循环,影响了远期疗效的进一步提高。
Using iodized oil and large doses of doxorubicin, mitomycin, cisplatin, and other chemical embolic agents, the catheter and tumor vessels were fully embolized with catheters, and larger doses of interleukin-2, alpha-interferon were used Hepatic arterial perfusion was given to adoptive immunotherapy to treat 124 cases of advanced primary liver cancer (including 2 cases of ruptured hepatocellular carcinoma). There were 35 cases of simple type II and 2 cases of stage III; 82 cases of stage II sclerosis and 3 cases of stage III; 2 cases of stage II inflammation. The total effective rate of treatment was 93.5%, of which 32.3% was reduced by more than 50%. So far, the average survival time of the whole group has reached 7.6 months. However, of the 6 cases with repeated embolization treatment 4 times or more, 4 cases developed collateral circulation, which affected the further improvement of long-term efficacy.