可乐定作为中枢性降压药早为人们所认识 ,但在临床麻醉镇痛的应用上则起步不久。本文就其在围手术期的应用和不良反应 ,特别是镇痛应用及其机制进行综述。 Clonidine as a central antihypertensive drug as early as people know, but the application of clinical anesthesia and analgesia started very soon. This article reviews its application in perioperative period and adverse reactions, especially the analgesic application and its mechanism.