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具生物活性的肽类及多肽的化学合成可采取收敛方法缩合已保护的肽片段形成目标分子。一种肟类载体的应用使保护肽中间体的合成较易进行,并使此法可用于二级结构单元已重组的肽类的合成。这些方法还扩展到更长肽链及蛋白质的合成。本文介绍了这些方法并列出了以此法对阿朴脂蛋白模型、果蝇触角基因控制的促生长蛋白类似区域结构、Cro 抑制因子的一部分以及核糖核酸酶T_1和其结构类似物等进行合成的实例。
Chemical Synthesis of Bioactive Peptides and Polypeptides Convergence methods can be used to condense the protected peptide fragments to form the target molecule. The use of an oxime carrier facilitates the synthesis of protective peptide intermediates and allows the method to be used for the synthesis of peptides that have been recombined with secondary structural units. These methods also extend to longer peptide chains and protein synthesis. This article describes these methods and lists the synthesis of the apolipoprotein model, the analogous region of the growth regulatory protein controlled by the flies antennae, a subset of Cro inhibitors, and the ribonuclease T_1 and its structural analogues Example.