一氧化氮(NO)作为一种新型的信使分子,在生理和病理过程中起着重要作用。近年来发现NO与脊髓水平的伤 害性信息调控密切相关,许多证据表明NO在脊髓内促进痛觉过敏的形成和发展,抑制NO的生成具有明显的抗伤害作用。但 也有一些不同的观点。本文对此作一综述。 Nitric oxide (NO), as a novel messenger molecule, plays an important role in physiological and pathological processes. In recent years, it is found that NO is closely related to the regulation of nociceptive information on spinal cord level. Many evidences suggest that NO promotes the formation and development of hyperalgesia and inhibits NO production in the spinal cord with obvious anti-injury effects. But there are some different points of view. This article gives a summary of this.