非甾体抗炎药(NSAIDs)的药理作用主要是抑制前列腺素的生成。老年人,尤其是女性,因易患骨关节炎、类风湿性关节炎、强直性脊椎炎等肌骨胳疾病,广泛以此类药作为控制症状。最常见的不良反应是上腹部不适和消化道出血,但尚缺乏确实证据以肯定其间的因果关联。最近Somerville等 The pharmacological actions of non-steroidal anti-inflammatory drugs (NSAIDs) are mainly to inhibit prostaglandin production. Elderly people, especially women, are prone to control the symptoms of musculoskeletal diseases such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. The most common adverse reactions are upper abdominal discomfort and gastrointestinal bleeding, but there is no conclusive evidence to confirm the causal link between them. Recently Somerville et al