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无论在实验上还是在人体,盐皮质类固醇的肾排酸作用业已证实。但在肾上腺皮质低功综合征时,醛固酮的直接作用尚未肯定。为此,作者对8例无亲缘关系的先天性肾上腺皮质增主症(CAH)小儿,就醛固酮在肾排酸调节中的选择性作用进行了研究。材料与方法8例21-羟化酶缺乏的CAH患儿,男5例,女3例;年龄1～11岁。均有盐水丢失,高钾血症、血浆肾素活性(PRA)增高和17-羟孕酮增高。在下述三组不同因素所致的代谢环境下,对肾脏酸碱平衡进行了研究。
Both in the experiment and in the human body, renal acidosis of mineralocorticoid has been confirmed. However, in the adrenal low-power syndrome, the direct effect of aldosterone has not been affirmed. To this end, the author of eight unrelated cases of congenital adrenal hyperplasia (CAH) in children, aldosterone in the regulation of renal acidosis were studied. Materials and Methods 8 cases of 21-hydroxylase-deficient CAH children, 5 males and 3 females; aged 1 to 11 years old. Both have lost salt water, hyperkalemia, plasma renin activity (PRA) increased and 17-hydroxyprogesterone increased. Kidney acid-base balance was studied in the metabolic environment of three different sets of factors described below.