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为比较甲磺酸左氧氟沙星（ＭＳＡＬＶＬＸ）注射液与对照药氧氟沙星和环丙沙星治疗细菌性感染疾病的临床疗效和体外抗菌活性，１９９８ 年５ 月至８ 月，由三个医疗中心采用随机对照，共同完成了２１３ 例，其中ＭＳＡＬＶＬＸ注射液组１１０ 例，氧氟沙星组８３例，环丙沙星组２０例。给药方法：ＭＳＡＬＶＬＸ组２００ｍ ｇ／１００ｍ ｌ静脉滴注，每日１次；氧氟沙星和环丙沙星组均为２００ｍ ｇ／１００ｍ ｌ静脉滴注，每日２次。疗程５～１４ｄ。结果显示，ＭＳＡＬＶＬＸ、氧氟沙星和环丙沙星的总有效率分别为９５．５％ 、８７．９％ 和８０％ ；它们的细菌清除率分别为９４．８％ 、８７．１％ 和８８．８％ ；致病菌对ＭＳＡＬＶＬＸ的敏感率（８８．１％ ）显著高于氧氟沙星（６９．７％ ，Ｐ＜ ０．０１）和环丙沙星（７０．８％ ，Ｐ＜ ０．０１），ＭＳＡＬＶＬＸ的抗菌活性高于氧氟沙星和环丙沙星。
To compare the clinical efficacy and in vitro antibacterial activity of MSALVLX injection with the control drug of ofloxacin and ciprofloxacin in the treatment of bacterial infections, from May to August 1998, three medical centers A total of 213 cases were randomized and controlled, including 110 MSALVLX injection group, 83 ofloxacin group and 20 ciprofloxacin group. Methods of administration: MSALVLX group 200m g / 100m l intravenous infusion, 1 day; ofloxacin and ciprofloxacin group were 200m g / 100m l intravenous infusion, 2 times a day. Course of treatment 5 ~ 14d. The results showed that the total effective rates of MSALVLX, ofloxacin and ciprofloxacin were 95.5%, 87.9% and 80%, respectively. Their bacterial clearance rates were 94.8% and 87.1%, respectively 88.8%. The sensitivity of pathogenic bacteria to MSALVLX was significantly higher than that of ofloxacin (69.7%, P <0.01) and ciprofloxacin (70.8%, P <0.01). The antibacterial activity of MSALVLX was higher than that of ofloxacin and ciprofloxacin.