论文部分内容阅读
黄腐酸是一种来源于风化煤、泥炭或褐煤的天然有机质,目前广泛应用于医药、农业、畜牧业等产业.前期研究表明黄腐酸具有抗炎、抗病毒、抗胃溃疡、抗肿瘤等活性,且活性因其产地和来源不同产生差异.本研究中,首次运用乙醇诱导小鼠胃溃疡模型评价产自云南三地(峨山、寻甸、昭通)褐煤源黄腐酸对胃损伤的保护作用,以及这三地黄腐酸对幽门螺旋杆菌的抑菌作用.结果显示:三地产黄腐酸均能显著提高胃组织中MDA和GSH的含量以及胃血清中SOD活性.同时,峨山和寻甸两地产黄腐酸在剂量为100 mg/m L和150 mg/m L时显示良好抑制幽门螺旋杆菌的活性.
Fulvic acid is a kind of natural organic matter derived from weathering coal, peat or lignite and is widely used in medicine, agriculture, animal husbandry and other industries.Previous studies have shown that fulvic acid has anti-inflammatory, anti-virus, anti-ulcer, anti-tumor Etc. In this study, the model of gastric ulcer induced by ethanol was first used in this study to evaluate the effect of fulvic acid from fulvic acid sources in three places of Yunnan (Asan, Xundian, Zhaotong) on gastric injury Protective effect and bacteriostatic action of these three fulvic acids on Helicobacter pylori.The results showed that fulvic acid could significantly increase the content of MDA and GSH in gastric tissue and the activity of SOD in gastric serum.At the same time, Fulian fulvic acid showed good inhibition of H. pylori activity at doses of 100 mg / m L and 150 mg / m L.