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目的探讨INSur E技术治疗早产儿呼吸窘迫综合征的临床疗效。方法选取2010年至2011年于我院进行治疗的25例患呼吸窘迫综合征的早产儿为对照组,应用持续正压通气的呼吸支持方法治疗;2012年至2013年23例患呼吸窘迫综合征的早产儿为观察组,采用INSURE技术治疗。比较两组患儿治疗前后动脉血气分析(包括动脉血氧分压Pa O2、二氧化碳分压Pa CO2、氧合指数Pa O2/Fi O2、p H等)改善情况,以及呼吸支持使用时间、氧疗时间、住院时间、并发症等。结果两组治疗后24 h的p H、Pa O2、Pa O2/Fi O2均较治疗前有不同程度上升,Pa CO2均较治疗前有不同程度下降(P<0.05);观察组无创通气时间[(68.8±16.1)h]、氧疗时间[(8.5±3.6)d]、住院时间[(19.8±6.2)d]均优于对照组,且差异有统计学意义(P<0.05);观察组呼吸暂停、BPD发生率、有创通气与病死率均低于对照组(P<0.05)。结论早产儿呼吸窘迫综合征应用INSURE技术进行呼吸支持治疗能够缩短无创通气时间、住院时间,并发症少,且操作方便,安全性高。
Objective To investigate the clinical efficacy of INSur E in the treatment of respiratory distress syndrome in premature infants. Methods Twenty-five preterm infants with respiratory distress syndrome who were treated in our hospital from 2010 to 2011 were selected as the control group and were treated with continuous positive pressure ventilation in respiratory support. From 2012 to 2013, 23 patients with respiratory distress syndrome Of premature infants were observed and treated with INSURE technique. The arterial blood gas analysis (including arterial oxygen partial pressure Pa O2, partial pressure of carbon dioxide Pa CO2, oxygenation index Pa O2 / Fi O2, p H, etc.) before and after treatment was compared between the two groups in terms of improvement of respiratory support, oxygen therapy Time, hospital stay, complications and so on. Results The levels of p H, Pa O 2 and Pa O 2 / Fi O 2 in the two groups were all increased to some extent before treatment compared with those before treatment (P 0. 05). The duration of non-invasive ventilation in the observation group [ (68.8 ± 16.1) h, Oxygen therapy time (8.5 ± 3.6) d and hospital stay (19.8 ± 6.2) d were better than those of the control group (P <0.05). The observation group Apnea, BPD incidence, invasive ventilation and mortality were lower than the control group (P <0.05). Conclusion Respiratory distress syndrome in preterm infants with INSURE technique can shorten the duration of noninvasive ventilation, hospitalization time, fewer complications, and easy operation and safety.