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目的探讨冠心病(CHD)患者血中D-二聚体(D-dimer)、血小板膜糖蛋白(GP)的变化以及临床意义。方法分别测定20例稳定性心绞痛(SA)患者、48例不稳定性心绞痛(UA)患者、20例正常对照组体内的D-dimer、GP含量,并分析有无冠状动脉事件发生者之间的关系,以及与冠状动脉事件检出的敏感度。结果UA组D-dimer、GP含量与SA组、对照组相比较差异有统计学意义(P<0.01),而SA组与对照组相比均无统计学意义(均P>0.05)。有冠状动脉事件发生者与无冠状动脉事件发生者相比也有统计学意义(P<0.05),D-dimer、GPⅡb、GPⅢa对冠状动脉事件的检出均较为敏感。结论D-dimer、GPⅡb、GPⅢa可作为冠状动脉血栓形成的指标之一,并在一定程度上反映了冠状动脉事件发生的危险性。
Objective To investigate the changes of D-dimer and platelet glycoprotein (GP) in patients with coronary heart disease (CHD) and their clinical significance. Methods The levels of D-dimer and GP in 20 patients with stable angina pectoris (SA), 48 patients with unstable angina pectoris (UA) and 20 normal controls were measured and analyzed for the presence or absence of coronary events Relationship, and the sensitivity of detection of coronary events. Results The D-dimer and GP contents in UA group were significantly different from those in SA group and control group (P <0.01), but not in SA group and control group (all P> 0.05). There was also a statistically significant difference between those with or without coronary events (P <0.05). D-dimer, GPⅡb and GPⅢa were more sensitive to coronary events. Conclusion D-dimer, GPⅡb, GPⅢa can be used as one of the indicators of coronary thrombosis, and to some extent reflects the risk of coronary events.