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帕金森病(Parkinson disease,PD)的细胞替代策略基于这样一个思想,即移植的细胞可以重建纹状体的多巴胺能神经传导,尽管该病呈慢性进展过程并累及大脑的其他部位和功能,但是重建的神经环路至少可以在相当长的时间维持一定的神经功能。20年以前的实验业已证明在大鼠帕金森病模型
The strategy of cell replacement in Parkinson’s disease (PD) is based on the idea that transplanted cells can re-establish dopaminergic neurotransmission of the striatum, and although the disease is chronic and involves other parts and functions of the brain, Reconstructed neural circuits can maintain a certain degree of neurological function for at least a considerable amount of time. Experiments 20 years ago have demonstrated a model of Parkinson’s disease in rats