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目的 对 10例皮肤原发性CD30阳性间变性大细胞淋巴瘤 (ALCL)进行临床及组织病理学研究 ,为临床病理早期诊断提供依据。方法 采用组织病理学及免疫组织化学法 (LCA、CD2 0、CD30、CD4 5RO、CD68、EMA、CK和HMB4 5 )对 10例皮肤原发性CD30阳性ALCL进行观察。结果 组织病理学示瘤细胞体积大 ,呈多形性、圆形或椭圆形 ,胞浆丰富 ,核大 ,核分裂像多 ,常见R S样细胞和多核巨细胞 ,核仁明显。免疫组化标记CD30阳性 ,其中 6例同时表达CD4 5RO ,1例表达CD2 0 ,非T非B表达 3例。随访发现 2例因肿瘤转移死亡 ,2例复发 ,6例无复发。结论 皮肤原发性CD30阳性ALCL是具有独特形态特点且预后较好的肿瘤。组织病理学特征及CD30阳性在鉴别诊断时具有重要意义
Objective To investigate the clinical and histopathological features of 10 cases of primary CD30 positive anaplastic large cell lymphoma (ALCL) and provide evidence for the early diagnosis of clinical pathology. Methods 10 cases of primary CD30 positive ALCL were examined by histopathology and immunohistochemistry (LCA, CD20, CD30, CD4 5RO, CD68, EMA, CK, and HMB4 5). Results Histopathology showed that the tumor cells were bulky, polymorphous, round or oval, with abundant cytoplasm, large nucleus, and more mitoses, common R S-like cells and multinucleated giant cells, and prominent nucleoli. Immunohistochemical markers of CD30 were positive, including 6 cases of CD4 5RO expression, CD2 0 in 1 case, 3 cases of non-T non-B expression. Follow-up found 2 patients died of tumor metastasis, 2 patients relapsed, and 6 patients had no recurrence. Conclusion Primary CD30 positive ALCL in skin is a tumor with unique morphological features and good prognosis. Histopathological features and positive CD30 are important in differential diagnosis