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固化剂异佛尔酮二异氰酸酯(IPDI)广泛用于工业生产,其分子结构为含两个NCO官能团的非芳香族二异氰酸酯。本文报告其致畸效应及胚胎毒性。选用Wistar成年健康大白鼠,按传统致畸试验进行。结果表明:(1)IPDI对孕鼠体重的增长有减缓作用,对胚胎着床率,着床前死亡无明显影
Curing agent isophorone diisocyanate (IPDI) is widely used in industrial production and its molecular structure is a non-aromatic diisocyanate containing two NCO functional groups. This article reports its teratogenic effects and embryotoxicity. Selection of Wistar adult healthy rats, according to the traditional teratogenic test. The results showed that: (1) IPDI had a slowing effect on body weight gain of pregnant rats, but no significant effect on embryo implantation rate and pre-implantation death