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本文应用免疫组织化学S－P法对40例膀胱移行细胞癌石蜡组织C－erbB－2基因表达与病理分级、临床分期和复发之间的关系进行研究，结果膀胱移行细胞癌C－erbB－2基因表达阳性率为40％。Ⅲ级与Ⅰ级、Ⅱ级肿瘤间存在显著性差异（P＜O．05），浅表性肿瘤与浸润性肿瘤间无显著性差异（O．05＜P＜O．10）复发组与未复发组之间有显著性差异（P＜0．05）。提示C－erbB－2基因表达对判断膀胱癌预后有一定临床价值。
The relationship between C-erbB-2 gene expression and pathological grade, clinical stage and recurrence in paraffin-embedded tissue of bladder transitional cell carcinoma was studied by immunohistochemical S-P method. The results showed that the expression of C-erbB-2 The positive rate of gene expression was 40%. There was a significant difference between grade Ⅲ and grade Ⅰ and grade Ⅱ tumors (P <0.05). There was no significant difference between superficial and invasive tumors (P> 0.05) There was significant difference between recurrence group (P <0.05). It is suggested that C-erbB-2 gene expression has some clinical value in judging the prognosis of bladder cancer.