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应用有效的溶解血栓药物治疗肺栓塞是有争议的。特别对其适应证,剂量疗程和使用方法(末梢的或中心血管滴注的)尚不明确。尿激酶静滴12小时后对肺血管阻塞的血栓溶解作用(经血管造影证实)较肝索静滴疗效明显。其有效程度按四级分可达1.7的标准度。本文报告12例;男8女4,平均年龄47(31～71)岁,皆有心悸、胸痛、气促和出汗等症状加剧到监护室治疗。全部病人首剂用尿激酶250,000u注入肺动脉,然后按2000u/kg/h经肺导管持续滴注12小时。同时用肝素15～20u/kg/h静滴,继续用药视凝血等化验结果而定,尿激酶剂量依纤维蛋白原浓度而定,其浓度值维持在50～100mg/dz。肝素剂量视凝血酶时
The use of effective thrombolytic drugs in the treatment of pulmonary embolism is controversial. In particular, its indications, dosage regimens and methods of use (peripheral or central vascular instillation) is not yet clear. Urokinase 12 hours after intravenous infusion of pulmonary vascular occlusion of the thrombolytic effect (confirmed by angiography) than the hepatic vein infusion obvious effect. The degree of validity according to four scores up to 1.7 standard. This article reports 12 cases; male and 8 female 4, the average age of 47 (31 to 71) years old, all have heart palpitations, chest pain, shortness of breath and sweating and other symptoms aggravated to the care room. All patients were injected with 250,000 u of urokinase for the first dose into the pulmonary artery, and then continued to drip for 12 hours by pulmonary catheter at 2000 u / kg / h. At the same time with heparin 15 ~ 20u / kg / h intravenous infusion, continued treatment depending on blood coagulation and other laboratory tests, urokinase dose according to the concentration of fibrinogen, the concentration was maintained at 50 ~ 100mg / dz. Heparin dose as thrombin