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吡磺环已脲(glipizide)是最新的第二代口服降糖药之一,于1971年合成,属环已基结构。 N 在胰岛素分泌的快速相或长期用药的反应方面,均是一种强力的胰岛素促泌剂。经过广泛的临床观察后,已普遍在西方国家应用。有关本药的报道很多,现综合部分资料如下。临床药理动力学吡磺环已脲吸收快,作用迅速,口服5mg在30分钟内可见免疫反应胰岛素(immunoreactive insulin,IRI)升高和血糖下降。半寿期约2～4h。口服单剂2.5mg后,其降血糖作用及其在血中消失时间约为10h。甲磺丁脲(tolbutamide)和氯磺丙脲(chlorpropamide)在血中的有效浓度约为50～100μmol/L,而吡磺环已脲仅为50～100nmol/L。如在药物重量
Glipizide urea (glipizide) is the latest second-generation oral hypoglycemic agents, synthesized in 1971, is a ring-based structure. N is a potent insulin secretagogue in terms of the rapid phase of insulin secretion or long-term drug use. After a wide range of clinical observations, has been widely used in Western countries. There are many reports on this drug, some of the information is summarized below. CLINICAL PHARMACOLOGY DYNAMICS Syphilis has a fast absorption and rapid action of urea, with an increase in immunoreactive insulin (IRI) and a decrease in blood glucose within 5 minutes after oral administration of 5 mg. Half-life of about 2 ~ 4h. Oral a single dose of 2.5mg, its hypoglycemic effect and its disappearance in the blood of about 10h. The effective concentration of tolbutamide and chlorpropamide in the blood is about 50-100 micromol / L, whereas the sulfonylurea is only 50-100 nanomol / L. As in the weight of the drug