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目的 :比较国产氨舒钠 (ASN)和进口优立新 (ULX)制剂 (均由氨苄西林 (AMP)与舒马坦 (SBT)以 2 :1比例组成 )的体外抗菌活性。方法 :采用平皿二倍稀释法 ,多点接种仪点种细菌测定最小抑菌浓度 (MIC) ,并观察药物的MBC及接种菌量、pH、血清浓度改变对药物抗菌作用的影响。结果 :AMP与ASN或ULX对革兰阳性菌的MIC50 之平均比值分别为 4 8和 5 1;对革兰阴性菌的平均MIC50 比值分别为 6 3和 6 6 ;ASN和AMP的MBC为 2～ 4×MIC。接种菌量在 10 3 ～ 10 9CFU/ml、pH值在 5～ 9及血清浓度在 0 %～ 2 0 %的范围内 ,药物的MIC仅提高 1～ 4倍。结论 :SBT能增强氨苄西林的抗菌活性 ;接种菌量、pH、血清浓度改变对药物抗菌活性无明显影响。
OBJECTIVE: To compare the in vitro antibacterial activity of amilorubicin (ASN) and imported ULX (2: 1 ratio of both ampicillin (AMP) and sultamol (SBT)). Methods: The minimum inhibitory concentration (MIC) was determined by two-point dilution method and multi-point inoculation method. The effect of MBC, inoculum size, pH and serum concentration on the antibacterial activity of the drug was observed. RESULTS: The average MIC50 ratios of AMP to ASN or ULX against Gram-positive bacteria were 48 and 51, respectively. The MIC50 ratios against Gram-negative bacteria were 6 3 and 6 6, respectively. The MBC of ASN and AMP were 2 ~ 4 × MIC. Inoculation bacteria in the 10 3 ~ 109CFU / ml, pH value of 5 to 9 and serum concentration in the range of 0% ~ 20%, the drug MIC increased only 1 to 4 times. Conclusion: SBT can enhance the antibacterial activity of ampicillin. Inoculation amount of bacteria, pH and serum concentration had no significant effect on antibacterial activity of ampicillin.