1962年 Pier Luca 报道氯丙嗪有抑制青蛙由绒毛膜促性腺激素所引起的排精作用。1971年 Gree-abery 首次报道,氯丙嗪对人在适当剂量时性欲和勃起都增加,但在性交快感时没有精液流出,即所谓的“干性”(dry sex)。此外,在1975年 Kailack Kedia报道,为了避孕目的,有二人用甲硫哒嗪(与氯丙嗪同属苯噻嚷衍生物)1～8个月,发现受试者在服药期间,性功能完全正常,他们也都没有精液射出,该作者指出,用这种药作为男性避孕药是有前途的。为此,我们在小鼠电射精的模型上观察了氯丙嗪 In 1962 Pier Luca reported that chlorpromazine inhibited the frog’s chorionic gonadotropin-induced ejaculation. Gree-abery first reported in 1971 that chlorpromazine had increased libido and erection in humans at the appropriate doses, but no seminal efflux at sexual pleasure, the so-called “dry sex.” In addition, in 1975, Kailack Kedia reported that for contraceptive purposes, two had methotrexate (both phenazonium derivatives and chlorpromazine) for 1 to 8 months, and found that during the medication, the subjects had complete sexual function Normal, they also have no sperm injection, the authors pointed out that the use of this drug as a male contraceptive is promising. For this reason, we observed chlorpromazine on the model of mouse ejaculation