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作者应用维生素 K 制剂治疗胆绞痛40例,其中胆结石34例,胆道蛔虫症6例。在绞痛发作时用药,一律肌内注射,每次用量 K_1 20毫克或 K_3 8毫克。结果对胆石症绞痛有效率约85%,对胆道蛔虫症绞痛有效率仅50%。绞痛消失的29例中,有22例仅给药一次,在住院期间绞痛即未再发作。药效出现于给药后的5～40分钟,多数病例显效于给药后的15分钟。在探讨 K 制剂治疗胆绞痛作用机理中,发现 K 制剂对离体豚鼠胆囊和狗总胆管平滑肌标本无松弛作用,相反,能显著增强麻醉狗在位肠管肠蠕动和总胆管括约肌紧张度,并轻度收缩总胆管平滑肌。对麻醉
The author applied vitamin K preparation for the treatment of 40 cases of biliary colic, including 34 cases of gallstones, 6 cases of biliary ascariasis. In the onset of colic medication, all intramuscular injection, each dosage K_1 20 mg or K_3 8 mg. The results of gallstone angina about 85% effective rate of biliary ascariasis angina only 50%. Among the 29 cases of colic disappearing, 22 cases were given only once and no colic was found during hospitalization. Efficacy appears in the medication after 5 to 40 minutes, most cases markedly effective after 15 minutes of administration. In discussing the mechanism of action of K preparation in treating biliary colic, we found that K preparation has no relaxation effect on isolated gallbladder and dog bile duct smooth muscle specimens from guinea pigs, on the contrary, it can significantly enhance intestinal peristalsis and total biliary sphincter tension in anesthetized dogs Slight contraction of total bile duct smooth muscle. Anesthesia