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目的探讨微波与微波术后联用白细胞介素-2(简称IL-2,下同)治疗外阴尖锐湿疣的临床效果。方法对比2004年以来我院皮肤科门诊治疗的148例外阴尖锐湿疣患者,分微波组107例单纯应用微波治疗,微波术后局部注射IL-2组者41例。结果单纯应用微波总有效率为84.1%;微波术后局部注射IL-2治疗总有效率95.1%,两组差异有统计学意义(P<0.01)。随访6个月,微波组复发率达70.1%;而微波术后局部注射IL-2复发率仅为7.3%,两组相比,存在显著性差异(P<0.001)。结论微波治疗术后再应用局部注射IL-2的方法治疗尖锐湿疣的临床效果优于单纯应用微波治疗。
Objective To investigate the clinical effect of combined treatment of genital warts with interleukin-2 (IL-2, the same below) after microwave and microwave surgery. Methods A total of 148 patients with vulvar condyloma acuminatum treated in dermatology outpatient department in our hospital from 2004 were compared with 107 cases treated with microwave alone in microwave group and 41 cases with local injection of IL-2 after microwave operation. Results The total effective rate of pure microwave application was 84.1%. The total effective rate of local injection of IL-2 after microwave operation was 95.1%. There was significant difference between the two groups (P <0.01). After 6 months of follow-up, the recurrence rate was 70.1% in microwave group. The recurrence rate of IL-2 after microwave operation was only 7.3%. There was significant difference between the two groups (P <0.001). Conclusion Microwave treatment of local injection of IL-2 after the treatment of genital warts clinical effect is better than the simple application of microwave treatment.