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目的:探讨双冬胶囊对膀胱收缩的影响。方法:观察记录给药双冬胶囊后30、60、90min大鼠的膀胱收缩曲线;给药后开始收集家兔尿量。结果:双冬胶囊降低大鼠在体膀胱收缩幅度,给药前后自身比较,中剂量组给药后60min和90min有统计学差异(P<0.01),大剂量组给药后30、60、90min均有统计学差异(P<0.01);膀胱收缩频率:给药前后自身比较,各剂量组给药后60min均有统计学差异(P<0.05);双冬胶囊可增加正常家兔的尿量,与阴性对照组比较,中剂量组给药后30min和60min有统计学差异(P<0.01),大剂量组给药后30min、60min、90min、120min均有统计学差异(P<0.05或P<0.01)。结论:双冬胶囊抑制膀胱收缩及利尿作用。
Objective: To investigate the effects of Shuangdong Capsule on bladder contraction. Methods: The contractile curve of bladder in rats at 30, 60 and 90 minutes after administration of Shuangdong Capsule was observed and recorded. Urine volume of rabbits was collected after administration. Results: Shuangdong Capsule reduced the contractile amplitude of the bladder in vivo. Compared with the control group before and after administration, Shuangdong Capsule showed statistical difference at 60min and 90min after administration (P <0.01), and 30,60 and 90min after administration (P <0.01). Bladder contraction frequency: Before and after administration, there was a significant difference at 60 min after administration (P <0.05). Shuangdong capsule could increase urine output of normal rabbits , Compared with the negative control group, there was a significant difference between the middle dose group 30min and 60min (P <0.01), and the high dose group 30min, 60min, 90min and 120min after administration (P <0.05 or P <0.01). Conclusion: Shuangdong Capsule can inhibit bladder contraction and diuretic effect.