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目的对我们设计的筛选抗运动病药物的动物实验方法进行有效性验证，比较两种抗运动病药物的效果。方法以正负交变加速度旋转刺激，诱发大鼠运动病。１６只大鼠以自身对照进行实验，分别给予大鼠两种抗运动病药物吗嗪及东莨菪碱与右旋苯丙胺合剂（以下简称合剂）后，观察大鼠嗜食高岭土量的变化，评价两种药物的抗运动病效果。结果服两种药后大鼠的食土量都明显减少（Ｐ＜０．０１；Ｐ＜０．０５），比较在同一条件下两种药物组间药效，服合剂后的食土量减少的效果优于服用吗嗪。结论所设计的诱发大鼠运动病模型是可靠的，是实验室研究抗运动病药物的较好方法。两种药物中合剂的抗运动病效果优于吗嗪。
Objective To validate the experimental animal experiments designed to screen anti-motion sickness drugs and to compare the effects of two anti-motion sickness drugs. Methods Rotational stimulation with positive and negative alternating acceleration induced motion sickness in rats. Sixteen rats were tested with their own control. Two anti-motion sickness drugs, morphine, scopolamine and dextroamphetamine (hereinafter referred to as mixture), were respectively administered to rats to observe the changes of the amount of the feeding kaolin in rats and to evaluate the effects of the two drugs Anti-motion sickness effect. Results After taking both drugs, the amount of soil and food in the rats decreased significantly (P <0.01; P <0.05). Compared with the control group, The effect is better than taking mosquito. Conclusion The induced rat model of motion sickness is reliable and is a good way to study anti-motion sickness drugs in the laboratory. The combination of two drugs in the anti-motion sickness effect is better than the mosquito.