目的隐球菌性脑膜炎是一种预后严重的深部真菌感染,早期误诊率达90％,死亡率和严重病残率分别高达25％～60％和20％以上,本研究目的是建立一套隐球菌脑膜炎的早期综合诊断与治疗方法。方法建立套式PCR用于隐球菌的检测,结合乳胶凝集试验检测隐球菌荚膜多糖抗原,用于隐球菌脑膜炎的早期筛选与诊断。提出在高颅压下(包括 Objective Cryptococcal meningitis is a deep-seated fungal infection with a severe prognosis. The early misdiagnosis rate is 90%, and the mortality rate and severe morbidity rate are as high as 25% -60% and 20%, respectively. The purpose of this study is to establish a set of implicit Early comprehensive diagnosis and treatment of cocci meningitis. Methods The nested PCR was used to detect Cryptococcus neoformans. The latex agglutination test was used to detect the capsular polysaccharide antigen of Cryptococcus neoformans, which was used in the early screening and diagnosis of cryptococcal meningitis. Proposed in the intracranial pressure (including